Characterization of Canine Herpesvirus Glycoprotein D (Hemagglutinin).

Reproductive Effects of Canine Herpesvirus

CE Email comments/questions to [email protected], fax 800-556-3288, or log on to www.VetLearn.com Canine herpesvirus type 1 has widely different effects, depending on the signalment of the exposed animal. Infection in adults is often inapparent, and latency follows. However, self-limiting lesions can occur on the genitalia of sexually active animals. Reproductive failure manifests as ear...

Genome Sequence of Canine Herpesvirus

Canine herpesvirus is a widespread alphaherpesvirus that causes a fatal haemorrhagic disease of neonatal puppies. We have used high-throughput methods to determine the genome sequences of three viral strains (0194, V777 and V1154) isolated in the United Kingdom between 1985 and 2000. The sequences are very closely related to each other. The canine herpesvirus genome is estimated to be 125 kbp i...

Entry Mediator Glycoprotein Binding to the Herpesvirus from Herpes Simplex Virus Modulates Functional Region IV of Glycoprotein D

Functional region IV of glycoprotein D from herpes simplex virus modulates glycoprotein binding to the herpesvirus entry mediator.

Glycoprotein D (gD) of herpes simplex virus (HSV) is essential for virus entry and has four functional regions (I to IV) important for this process. We previously showed that a truncated form of a functional region IV variant, gD1(Delta290-299t), had an enhanced ability to block virus entry and to bind to the herpesvirus entry mediator (HveAt; formerly HVEMt), a cellular receptor for HSV. To ex...

Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology

The viral envelope glycoprotein D from bovine herpesviruses 1 and 5 (BoHV-1 and -5), two important pathogens of cattle, is a major component of the virion and plays a critical role in the pathogenesis of herpesviruses. Glycoprotein D is essential for virus penetration into permissive cells and thus is a major target for virus neutralizing antibodies during infection. In view of its role in the ...